BiotechHealth

Biotechhealth PhD student Vanessa Nunes published in Molecular Biology of the Cell

Biotechhealth PhD student Vanessa Nunes published in Molecular Biology of the Cell journal

Vanessa Nunes, Margarida Dantas, Domingos Castro, Elisa Vitiello, Irène Wang, Nicolas Carpi, Martial Balland, Matthieu Piel, Paulo Aguiar, Helder Maiato, and Jorge G. Ferreira. Centrosome-nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity. Molecular Biology of the Cell (Journal). Doi: 10.1091/mbc.E20-01-0047

Centrosome positioning during prophase is not random! We have shown that centrosomes-nucleus axis reorients during prophase so that centrosomes are positioned on the shortest nuclear axis at nuclear envelope breakdown. This allows the establishment of an initial bipolar spindle scaffold, facilitating chromosome capture and segregation. Moreover, we have demonstrated that while nuclear motion is controlled by dynein on the nuclear envelope, centrosome movement is induced by Arp2/3-mediated regulation of microtubule dynamics.