José Carlos Machado

The question that drives our research is how genetic information is transmitted among the diverse cellular constituents of a tumor, and how that impacts on the heterogeneity and plasticity of tumor cells. Tumor heterogeneity is a key determinant of tumor development and evolution, and is often a confounder in tumor evaluation for diagnosis and treatment. We aim at translating basic research into clinically relevant information with impact on the capacity to deal with cancer progression, drug resistance and, ultimately, patient survival.

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