Maria José Oliveira

At i3S, the Microenvironments in cancer invasion and metastasis Team has been mainly focused on the effect of macrophages, present at the tumor microenvironment, on the regulation of cancer cell invasion, motility/migration and proteolysis, dissecting the associated molecular mechanisms. We demonstrated that anti-inflammatory macrophages (IL-10-stimulated) are more efficient in promoting in vitro cancer cell invasion and migration and in vivo cancer cell-induced angiogenesis than their pro-inflammatory (LPS-stimulated) counterparts. Our current research is dedicated to the design of an immunomodulatory therapy to counteract macrophage-mediated cancer cell invasion and metastasis.